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Updated: May 30, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

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Perinatal Mood and Anxiety Disorders: Evidence-Based Approaches to Screening and Management During Pregnancy and

Clara Bertozzi-Villa1, Rubiahna Vaughn2, Sameer Khan3

  • 1Department of Obstetrics and Gynecology, Montefiore Albert Einstein College of Medicine.

Obstetrics and Gynecology Clinics of North America
|January 29, 2025
PubMed

Insights

This review synthesizes literature and guidelines for perinatal mood and anxiety disorders, focusing on major depressive disorder and generalized anxiety disorder screening, management, and follow-up.

Area of Science:

  • Perinatal mental health
  • Psychiatry
  • Obstetrics and Gynecology

Background:

  • Perinatal mood and anxiety disorders (PMADs) are prevalent and impact maternal and infant well-being.
  • Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are common PMADs.
  • Effective screening, management, and follow-up are crucial for optimal perinatal mental healthcare.

Purpose of the Study:

  • To review current literature and clinical guidelines for PMADs.
  • To focus on evidence-based practices for MDD and GAD in the perinatal period.
  • To provide a comprehensive overview for clinicians and researchers.

Main Methods:

  • Systematic literature search of relevant databases.
  • Analysis of existing clinical practice guidelines.
  • Synthesis of findings on screening tools, treatment modalities, and follow-up protocols.

Main Results:

  • Identification of validated screening instruments for PMADs.
  • Summary of pharmacological and non-pharmacological management strategies for MDD and GAD.
  • Discussion of optimal follow-up schedules and supportive care interventions.

Conclusions:

  • Early detection and intervention are key for managing perinatal depression and anxiety.
  • Multidisciplinary approaches enhance treatment outcomes for mothers and infants.
  • Adherence to evidence-based guidelines improves the quality of perinatal mental healthcare.

Keywords:
Maternal and neonatal outcomes of PMADsPerinatal anxiety disordersPerinatal depressionPerinatal mood and anxiety disorders (PMADs)Screening tools for anxiety and depressionTreatment of PMADs

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