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Updated: May 29, 2025

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Published on: July 11, 2016
The Mass Spectrometry Revolution in Clinical Microbiology Part 1: History and Current Applications
1Division of Geographic Medicine and Infectious Diseases, Tufts University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Tufts University School of Medicine, Boston, MA, USA.
Abstract:
The introduction of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized infectious disease diagnostics over the past decade. In this review, we will first explore the history of how the once disparate fields of mass spectrometry (MS) and clinical microbiology inextricably merged. We will then review the rapid growth as well as current applications of MALDI-TOF MS in clinical microbiology. In the accompanying review, we will discuss some of the exciting and emerging applications of MS in pathogen detection, identification, and characterization.
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