Electrochemical flow injection analysis platforms for biomedical applications - Progress and prospects

Flow injection analysis coupled with electrochemical detection (FIA-ECD) techniques has to be a key technological development for wide variety of applications in various domains such as synthetic analytical chemistry, materials science, biomedical and point-of-care devices. FIA-ECD techniques have to be unique due to decreasing the time of analysis, sample pre-treatment, reactions and separation-free detection for multi-analytes. In biomedical domain, various electrochemical sensors were decorated with bioactive molecules, i.e., DNA, antibodies, enzymes along with biocompatible polymers for the detection of biologically important chemicals and analytes. The flexibility and practical applicability of these sensors may serve as a new pattern for clinical and biomedical analytical instrumentations. This review covers the highlights and overview of the most successful and promising electrochemical sensors, biosensors and immunosensors integrated with the flow injection analysis platforms, fabrication and analytical parameters, pros and cons of these sensor technologies, challenges and future opportunities in point-of-care clinical analysis.