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Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications.

Zhenwu Wang1, Zeng Lin1, Xuan Mei1

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|February 6, 2025
PubMed
Summary
This summary is machine-generated.

Gelatin and its derivatives are key biomaterials for engineered living systems (ELSs), enabling advanced fabrication techniques for diverse biomedical applications like regenerative engineering and cell therapies.

Keywords:
3D printingbiofabricationengineered living systemsgelatinhydrogels

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Tissue Engineering

Background:

  • Engineered living systems (ELSs) are purpose-driven assemblies of biological components for biomedical applications.
  • Gelatin and its derivatives are widely used in ELSs due to their biological compatibility and tunable properties.

Purpose of the Study:

  • To review the synergistic potential of gelatin derivatives and fabrication techniques in creating ELSs.
  • To explore the applications of gelatin-based ELSs in various biomedical fields.

Main Methods:

  • Comprehensive literature review of gelatin properties, fabrication methods, and ELS applications.
  • Analysis of generic fabrication, microfluidics, and 3D printing techniques with gelatin.
  • Examination of gelatin-based ELSs in regenerative engineering, cell therapies, bioadhesives, biorobots, and biosensors.

Main Results:

  • Gelatin's structure, production, sources, processing, and properties are detailed.
  • Various fabrication techniques utilizing gelatin and its derivatives are discussed.
  • Diverse applications of gelatin-based ELSs are presented, highlighting their versatility.

Conclusions:

  • Gelatin-based ELSs hold significant promise for advancing biomedical engineering.
  • Future research should focus on overcoming fabrication challenges and exploring innovations in gelatin-based ELSs.