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Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations
Published on: June 17, 2011
Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission
Hojeong Park1, Guangle Niu2, Alex Y H Wong3
1Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Neuroscience and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Abstract:
We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.
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