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Polyphenol-Modified Mg-Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic
Haibo Liu1,2,3, Zhongyi Sun2, Mengting Yin2
1Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, P. R. China.
Advanced Healthcare Materials
|February 11, 2025
Summary
A novel microneedle patch delivers quercetin-loaded nanosheets to diabetic oral ulcers. This approach enhances healing by reducing inflammation, fighting infection, and promoting tissue regeneration and blood vessel growth.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral Health
Background:
- Diabetic oral ulcers present significant healing challenges due to chronic inflammation and the oral cavity's dynamic environment, limiting conventional treatments.
- Sustained drug delivery is crucial for effective management, but challenges like salivary flow and muscle movement impede topical therapies.
- Developing innovative delivery systems is essential to overcome these barriers and improve therapeutic outcomes for diabetic patients.
Purpose of the Study:
- To develop a multifunctional soluble microneedle (MN) patch for enhanced transdermal delivery of bioactive components to diabetic oral ulcers.
- To load quercetin-modified Mg-Zn layered hydroxide salt (LHSQ) nanosheets into γ-polyglutamic acid (γ-PGA) based MNs for anti-inflammatory, antimicrobial, and pro-angiogenic effects.
- To evaluate the efficacy of these LHSQ-loaded MN (LHSQ-MN) patches in promoting the healing of diabetic oral ulcers.
Main Methods:
- Fabrication of multifunctional soluble microneedle (MN) patches using γ-polyglutamic acid (γ-PGA).
- Loading of quercetin (Qu)-modified Mg-Zn layered hydroxide salt (LHS) nanosheets (LHSQ) into the MNs.
- In vivo evaluation of LHSQ-MN patch efficacy in a rat model of diabetic oral ulcers, assessing tissue regeneration, inflammation, antibacterial activity, and angiogenesis.
Main Results:
- LHSQ-MN patches demonstrated effective penetration of the oral mucosa.
- Application of LHSQ-MN patches facilitated regeneration, regulated the inflammatory microenvironment, and exhibited potent antibacterial effects.
- Ulcer healing was accelerated through enhanced angiogenesis and expedited mucosal epithelium reconstitution.
Conclusions:
- LHSQ-MN patches show significant potential for transdermal delivery of therapeutic agents to diabetic oral ulcers.
- The developed MN system effectively addresses challenges in drug retention and delivery within the oral cavity.
- LHSQ-MN patches represent a promising therapeutic strategy for managing oral ulcers in diabetic patients, promoting faster and more effective healing.
