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Updated: May 28, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective 1,4-Hydroamination of 1,3-Dienes by Photoredox/Cobalt Dual Catalysis
Pei-Ting Li1, Quansheng Mou1, Wei Yu1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, China.
Abstract:
Herein, we report a visible-light-driven and cobalt-mediated 1,4-hydroamination reaction of 1,3-dienes with arylmines as the nucleophiles. The reaction involves regioselective addition of [CoIII]-H to 1,3-diene, followed by oxidation and nucleophilic substitution by amines. Using Ir(ppy)3 as the photocatalyst enables the cobalt redox cycle to be implemented without using an external oxidant and hydride regent. This protocol can be applied as well to forge the carbon-oxygen and carbon-sulfur bonds in an analogous way.
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