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Inflammation

Inflammation

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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On-Chip Endothelial Inflammatory Phenotyping

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Inflammation and endothelial gene polymorphism are associated with ischemic stroke.

Wanli Chen¹, Jie Li¹, Jintao Zhou²

¹Department of Neurology, The People's Hospital of Deyang City, Deyang, China.

Frontiers in Neurology

|February 20, 2025

Summary

Genetic variations in inflammation and endothelial function genes, specifically HABP2 rs7923349 and HABP2 rs932650, are linked to increased ischemic stroke risk. These gene interactions significantly elevate the likelihood of developing this condition.

Keywords:

endothelial function genetic polymorphism high-risk stroke population inflammation stroke

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Last Updated: May 27, 2025

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Area of Science:

Genetics
Cardiovascular Research
Epidemiology

Background:

Ischemic stroke is a leading cause of death and disability worldwide.
Genetic factors play a role in stroke etiology, particularly those influencing inflammation and endothelial function.
Understanding these genetic correlations can aid in risk stratification and prevention strategies.

Purpose of the Study:

To investigate the association between genetic variations in inflammation and endothelial function-related genes and the risk of ischemic stroke.
To explore gene-gene interactions among these variants using generalized multifactor dimensionality reduction (GMDR).

Main Methods:

A multicenter, cross-sectional study involving 429 ischemic stroke patients and 429 matched controls from southwestern China.
Genotyping of 19 variants in 10 genes associated with inflammation and endothelial function.
Analysis of gene-gene interactions using GMDR.

Main Results:

Univariate analysis identified associations between stroke and variants rs7923349 (HABP2), rs8081248 (NOS2A), and rs932650 (HABP2).
GMDR analysis revealed significant gene-gene interactions between HABP2 rs7923349 and HABP2 rs932650.
High-risk interactive genotypes of HABP2 rs7923349 and HABP2 rs932650 were independently associated with a 3.578-fold increased risk of ischemic stroke (p < 0.001).

Conclusions:

Specific genetic variations in genes regulating inflammation and endothelial function are significantly associated with ischemic stroke.
The combined effect of high-risk genotypes in HABP2 rs7923349 and HABP2 rs932650 substantially elevates the risk of ischemic stroke.