Promising Natural Remedies for Alzheimer's Disease Therapy
Amin Mahmood Thawabteh1,2, Aseel Wasel Ghanem2, Sara AbuMadi2
1Department of Chemistry, Birzeit University, West Bank, Ramallah 00972, Palestine.
Molecules (Basel, Switzerland)
|February 26, 2025
Summary
Natural compounds show promise for Alzheimer's disease (AD) treatment, enhancing memory and cognitive function. Further research is needed to confirm the efficacy of these herbal remedies, which are safer and more accessible than conventional options.
Area of Science:
- Neuroscience
- Pharmacology
- Natural Product Chemistry
Background:
- Alzheimer's disease (AD) poses a significant challenge, necessitating novel therapeutic strategies.
- Current treatments have limitations, driving the search for safer and more effective alternatives.
- Herbal extracts and natural compounds offer potential benefits for cognitive enhancement and AD management.
Purpose of the Study:
- To review the efficacy of phytoconstituents from various plants for improving memory and cognitive function in Alzheimer's disease.
- To identify natural compounds that may serve as future therapeutic agents for AD.
- To evaluate the safety, accessibility, and blood-brain barrier penetration of herbal medicines.
Main Methods:
- A literature review of peer-reviewed studies published between 2015 and 2024.
- Searched academic databases for research on natural substances and their effects on Alzheimer's disease.
- Focused on phytoconstituents isolated from plants with reported cognitive benefits.
Main Results:
- Identified 66 phytoconstituents from 21 different plants demonstrating efficacy relevant to AD.
- Herbal medicines showed benefits including improved cholinergic and cognitive function.
- These natural compounds are generally safer, more accessible, and readily cross the blood-brain barrier.
Conclusions:
- Phytoconstituents show encouraging potential for the development of novel Alzheimer's disease therapies.
- Herbal treatments present a promising, less harmful alternative to conventional AD interventions.
- Larger-scale, longer-duration studies are required to validate the therapeutic efficacy of these natural compounds for AD.
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