CORRELATION BETWEEN RHYTHMOGENESIS OF THE RAT URETERS UNDER HISTAMINE EXPOSURE

The work is devoted to the study of the interrelationship between the characteristics of spontaneous electrical activities in paired ureters in norm and after isolation. Analysis was conducted by detecting the amplitude (A), rise rate (V), rise-time (T/2), half-width (t), and frequency of rhythmogenesis (F) of pacemaker activity. In norm, the amplitude value exceeds in the left ureter that of the right ureter. Sequential isolation of the organs (left ureter, then right) results in a decrease in the action potential amplitude by 26%, which indicates a certain interconnection between them. Additionally, histamine exposure leads to a synchronous increase in both ureters in norm. Subsequent isolation of the left ureter leads to a significant increase in the amplitude - up to 171%, and rise rate - up to 158%, of the right ureter. These findings suggest that histamine contributes to the increased excitability and regulation between the two ureters. Thus, this hormone, by enhancing rhythmogenesis in the right ureter, may indicate certain potential for the overall functioning of the urinary system.