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Updated: May 25, 2025
Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
Impact of Clinicopathological Features on Gastric Cancer Stage According to TNM Classification
Oliwia Majewska1, Radosław Pach2, Paweł Brzewski1,2
1Andrzej Frycz Modrzewski Krakow University Faculty of Medicine and Health Sciences, Krakow, Poland.
Background/Aim:
TNM stage is crucial for patients with gastric cancer because curative resection and treatment are only possible in early TNM stages. Therefore, our objective was to assess the association of clinicopathological features with TNM stage in such patients.
Patients And Methods:
The association of age, sex, tumor location and Lauren type with TNM stage was analyzed in 910 patients with gastric cancer.
Results:
Age, sex, and tumor location did not have any association with TNM stage in univariate nor multivariate analyses (p>0.05). However, compared to the diffuse and mixed types, the intestinal type (as defined by the Lauren classification) presented lower T stage of gastric cancer in the chi-squared test (p<0.001) and this association was confirmed in the multinominal log normal model (p=0.001).
Conclusion:
The histological Lauren type of gastric cancer is associated with lower TNM T stage.
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