Related Experiment Video
Updated: May 24, 2025

Murine Model of Hindlimb Ischemia
Published on: January 21, 2009
[Acute limb ischaemia]
Josephine Dissing Bagge1, Nikolaj Eldrup1,2, Tim Resch1,2
1Afdeling for Karkirurgi, Københavns Universitetshospital - Rigshospitalet.
None:
Acute limb ischaemia is a vascular emergency with very high morbidity and mortality. It is defined by abrupt reduction in arterial perfusion and symptom duration of less than 14 days. The clinical presentations varies, but the six P's: pain, pallor, pulseless, paraesthesia, paralysis and perishingly cold, are present to some degree. Quick and efficient assessment is necessary, but amputation risk is high. Treatment options include catheter-directed thrombolysis, endovascular revascularization and open surgery. Endovascular treatment should be considered in patients with higher perioperative risk, as argued in this review.
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