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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

519
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
519
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

766
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
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Mass Analyzers: Overview01:13

Mass Analyzers: Overview

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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
527
Mass Spectrometers01:16

Mass Spectrometers

4.8K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
4.8K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization
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High-Performance Data Acquisition for Fourier Transform Mass Spectrometry.

Anton N Kozhinov1, Konstantin O Nagornov2, Yury O Tsybin3

  • 1Spectroswiss, EPFL Innovation Park, Building I, CH-1015 Lausanne, Switzerland. kozhinov@spectroswiss.ch.

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PubMed
Summary
This summary is machine-generated.

Spectroswiss FTMS Boosters enhance Fourier transform mass spectrometry (FTMS) performance, improving data acquisition and processing for advanced scientific applications. These systems boost mass resolution and sensitivity, extending the life of existing instruments.

Keywords:
Charge detection mass spectrometryComplex mixture analysisIsotope ratio analysisMass spectrometry imagingSuper-resolution mass spectrometry

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Data Science

Background:

  • High-performance data acquisition and processing (DAQ) systems are crucial for modern scientific research, particularly in mass spectrometry.
  • Fourier transform mass spectrometry (FTMS) platforms require advanced DAQ systems to handle increasing data complexity and volume.
  • Commercial solutions like Spectroswiss FTMS Boosters aim to enhance the capabilities of existing FTMS instruments.

Purpose of the Study:

  • To review the impact and applications of Spectroswiss FTMS Boosters in enhancing Fourier transform mass spectrometry (FTMS) performance.
  • To highlight the role of FTMS Boosters in improving mass resolution, sensitivity, and data handling across various analytical applications.
  • To assess the contribution of advanced DAQ systems to data-intensive scientific research.

Main Methods:

  • Review of Spectroswiss FTMS Booster technology and its integration with FTMS platforms (e.g., Orbitrap, ICR).
  • Analysis of FTMS Booster performance across six key application areas.
  • Evaluation of the impact on data acquisition, processing, and overall system capabilities.

Main Results:

  • FTMS Boosters significantly improve mass resolution, sensitivity, and data handling in FTMS instruments.
  • The technology demonstrates broad applicability across diverse fields including mass spectrometry imaging, biopharmaceutical analysis, and complex mixture analysis.
  • FTMS Boosters enhance the performance of legacy FTMS systems, offering a cost-effective upgrade path.

Conclusions:

  • FTMS Boosters represent a significant advancement in high-performance DAQ systems for FTMS.
  • These systems are vital for addressing the growing demands of big data in mass spectrometry and related scientific research.
  • The technology extends the utility and lifespan of existing FTMS infrastructure, promoting sustainable scientific advancement.