Midface Toddler Excoriation Syndrome (MiTES): A Review

Midface toddler excoriation syndrome (MiTES) is a rare dermatological condition characterized by chronic, self-inflicted excoriations of the midface, often leading to significant scarring and hyperpigmentation. It typically affects young children, with a male predominance. MiTES is linked to genetic mutations in the PRDM12 gene. Treatment approaches vary, including topical antimicrobials, emollients, steroids, and oral medications aimed at reducing scratching impulses. However, responses are inconsistent, and many patients show only partial or moderate improvement. This review consolidates current knowledge of MiTES, emphasizing its clinical features, genetic basis, and management strategies.