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Updated: May 22, 2025

07:33
In vivo Dual Substrate Bioluminescent Imaging
Published on: October 11, 2011
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BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc
Valeska Viereckt1, Frank Abendroth1, Alexander Schauerte2
1Department of Chemistry, Marburg University, Marburg, Germany. olalla.vazquez@staff.uni-marburg.de.
Abstract:
We report how the conjugation of coelenterazine (CTZ) to BODIPY retains its activity as a versatile substrate for luciferase-type enzymes opening the possibility of taking advantage of BODIPY's fluorescent properties and capacity to generate singlet oxygen. Bioluminescence imaging-guided photodynamic therapy or 1O2-triggered drug release are potential applications of these conjugates.

