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Related Experiment Video

Updated: May 22, 2025

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.

Woo-Jin Lee¹, Keun-Hwa Jung², Kyung-Il Park³

¹Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, South Korea.

|March 14, 2025

Summary

Brain volume changes and white matter abnormalities are linked to cognitive decline in older adults. Specific brain regions and white matter signal abnormality (WMSA) volumes show distinct associations with changes in different cognitive domains.

Keywords:

Brain aging Cognitive function domains Segmental brain volume White matter signal abnormality

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Last Updated: May 22, 2025

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Published on: September 25, 2019

Area of Science:

Neuroimaging
Cognitive Neuroscience
Gerontology

Background:

Longitudinal changes in cognitive function are a significant concern in aging populations.
Brain structure, including regional volumes and white matter integrity, plays a crucial role in maintaining cognitive abilities.
White matter signal abnormalities (WMSA) are common in older adults and may impact cognitive function.

Purpose of the Study:

To investigate the domain-specific associations between segmental brain volumes and white matter signal abnormality (WMSA) volumes with longitudinal cognitive changes.
To explore how changes in specific brain regions and WMSA relate to declines in different cognitive domains over time.

Main Methods:

Participants aged over 50 without central nervous system disorders underwent serial cognitive assessments (CERAD-K) and brain MRI.
Cognitive performance changes were analyzed in relation to baseline and follow-up brain volumes and WMSA volumes.
Statistical analyses examined the associations between neuroimaging markers and cognitive domain performance changes.

Main Results:

Global cognitive decline was associated with lower/decreasing hippocampus and amygdala volumes and increasing WMSA volumes.
Executive function decline linked to lower baseline hippocampus/amygdala volumes and increasing WMSA volumes.
Language, verbal learning, memory recall, and recognition memory declines showed specific associations with hippocampus/amygdala volumes and WMSA volumes.

Conclusions:

Brain volume and WMSA parameters demonstrate domain-specific relationships with longitudinal cognitive changes in older adults.
These findings suggest that different cognitive domains rely on brain reserve in distinct ways.
The study highlights the importance of considering regional brain changes and WMSA in understanding cognitive aging.