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[Clinical analysis of nutritional components in children with acute leukemia]

Li-Xia Shi1, Ming-Zhong Zhao, Fei-Fei Wang

  • 1Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|March 19, 2025
PubMed

Insights

Children with acute leukemia (AL) experience significant body composition changes, especially during chemotherapy. Early nutritional screening is vital for intervention and recovery, as muscle mass and balance are affected.

Area of Science:

  • Pediatric Oncology
  • Nutritional Science
  • Body Composition Analysis

Context:

  • Acute leukemia (AL) significantly impacts pediatric patients' health.
  • Body composition and nutritional status are critical during cancer treatment.
  • Understanding these changes is essential for effective patient management.

Purpose:

  • To evaluate body composition alterations in children with acute leukemia (AL) across different disease stages.
  • To identify specific nutritional risks and challenges faced by these children.
  • To compare body composition between AL patients and healthy children.

Summary:

  • Bioelectrical impedance analysis and anthropometry revealed age-related increases in non-fat mass for both AL patients and controls.
  • Older children with AL undergoing chemotherapy showed significantly lower body composition than healthy peers.
  • Post-chemotherapy, muscle mass recovery was observed first, with reduced trunk fat and increased body composition imbalance in AL survivors.

Impact:

  • Findings highlight the dynamic impact of AL and its treatment on pediatric body composition.
  • Results underscore the need for tailored nutritional interventions based on early screening.
  • This research provides a foundation for improving nutritional support and recovery strategies in pediatric oncology.
Abstract

Keywords:
Acute leukemiaBioelectrical impedanceBody compositionChildNutritional risk screening

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