Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

The Two-State Receptor Model

The Two-State Receptor Model

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...

The Equilibrium Binding Constant and Binding Strength

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:

Classical Conditioning in Daily Life

Classical Conditioning in Daily Life

Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...

Cooperative Binding of Transcription Regulators

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Theta band activity during event-file retrieval is influenced by stimulus salience in the preceding action episode.

Cortex; a journal devoted to the study of the nervous system and behavior·2026

Same author

Perception and action as one: Re-integrating research on human action through event files.

Psychological review·2026

Same author

Learned statistical regularity modulates anticipatory micro-saccades toward suppressed distractor locations.

Nature communications·2026

Same author

Binding and retrieval of omitted responses in complex response sequences.

Attention, perception & psychophysics·2026

Same author

From prediction to control: Age-related dissociations between implicit regularity encoding and attentional modulation during perception-action integration.

Developmental cognitive neuroscience·2026

Same author

A Multiplexed Neural Code Governs Dynamic Perception-Action Reconfiguration during Response Inhibition.

Journal of cognitive neuroscience·2026

Same journal

Orthographic Neighbourhood Size Effects in Chinese Character Recognition: Small, Inconsistent, and Theoretically Ambiguous.

Journal of cognition·2026

Same journal

The Role of Different Thoughts in Tacit Coordination and Its Malleability by Interventions.

Journal of cognition·2026

Same journal

The Impact of Prior Beliefs about Volatility on Adaptive Behavior.

Journal of cognition·2026

Same journal

Proactive Control of Emotional Information in Adult ADHD.

Journal of cognition·2026

Same journal

Knowledge Gap Illustrations Spark Curiosity.

Journal of cognition·2026

Same journal

Centre-of-Mass Confounds Contribute to Familiar Size Stroop Effects with Boger and Firestone's 'Visual Anagrams'.

Journal of cognition·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 20, 2025

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Habituation in Predictability-Modulations of Stimulus-Response Binding.

Philip Schmalbrock^1,2, Jan Theeuwes³, Christian Frings^1,2

¹Department of Psychology, University of Trier, DE.

Journal of Cognition

|March 25, 2025

Summary

This summary is machine-generated.

Stimulus predictability reduces action control binding effects. This study suggests statistical learning, not habituation, explains why predictable stimuli weaken stimulus-response binding, linking learning to action control mechanisms.

Keywords:

Action Control Habituation Predictability S-R binding effect Statistical Regularities

More Related Videos

Studying Habituation in Stentor coeruleus

Studying Habituation in Stentor coeruleus

Published on: January 6, 2023

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Related Experiment Videos

Last Updated: May 20, 2025

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Studying Habituation in Stentor coeruleus

Studying Habituation in Stentor coeruleus

Published on: January 6, 2023

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Area of Science:

Cognitive Psychology
Neuroscience
Action Control

Background:

Intentional action relies on integrating perceptual and action information into a unified representation, termed the event file.
Stimulus-response binding effects quantify this integration and are modulated by factors like stimulus predictability.
Predictability diminishes binding effects, but the underlying mechanism remains unclear.

Purpose of the Study:

To investigate the mechanisms behind the reduction of stimulus-response binding effects by stimulus predictability.
To compare habituation and statistical learning as potential explanations for this modulation.
To elucidate the relationship between learning and action control.

Main Methods:

A study with 234 participants was conducted.
Two hypotheses—habituation and statistical learning—were compared.
Behavioral measures were used to assess stimulus-response binding effects under varying predictability conditions.

Main Results:

Evidence against habituation as the primary explanation for predictability modulation.
Findings support statistical learning as a more likely mechanism, though not exclusively.
The study demonstrates a link between learning statistical regularities and action control.

Conclusions:

Stimulus predictability's impact on action control is likely mediated by statistical learning processes.
Habituation is an unlikely explanation for the observed modulation of stimulus-response binding.
This research contributes to understanding how learning mechanisms influence action control.