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Updated: May 20, 2025

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Leadless pacing in peri-procedural settings
Mikhael F El-Chami1, Ryan Cunnane2
1Division of Cardiology, Section of Electrophysiology, Emory University School of Medicine, 550 Peachtree Street, NE Atlanta, GA 30308, USA.
Summary
Leadless pacemakers (LPs) offer a safer alternative to traditional pacemakers by eliminating leads and pockets, reducing infection and complication risks. This review focuses on their benefits, particularly after valve replacement surgery.
Area of Science:
- Cardiology
- Medical Devices
- Cardiac Surgery
Background:
- Traditional transvenous permanent pacemakers (TV-PPMs) are associated with lead and pocket complications.
- Lead-related issues like dislodgement and pocket infections are significant concerns in pacemaker therapy.
Purpose of the Study:
- To review the role and advantages of leadless pacemakers (LPs) in patients undergoing valve replacement procedures.
- To highlight how LPs mitigate risks compared to TV-PPMs in specific clinical scenarios.
Main Methods:
- Review of observational studies and clinical data on leadless pacemakers.
- Comparative analysis of complication rates between LPs and TV-PPMs.
Main Results:
- Leadless pacemakers significantly reduce long-term complications, primarily by minimizing re-interventions.
- LPs demonstrate a lower incidence of infection and lead-related complications compared to TV-PPMs.
- These benefits are particularly pronounced in patients post-transcutaneous or surgical valve replacement.
Conclusions:
- Leadless pacemakers offer a superior safety profile by eliminating leads and subcutaneous pockets.
- The reduced risk of infection and lead complications makes LPs ideal for patients requiring valve surgery.
- LPs represent a significant advancement in cardiac pacing, especially for high-risk patient populations.

