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Updated: May 20, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Hydrophilic-coated sheaths for reducing radial artery spasm during transradial procedures: A systematic review and
Mishaal Hukamdad1, Kaho Adachi1, Youssef Soliman2
1University of Illinois College of Medicine, Chicago, IL, USA.
Abstract:
BackgroundTransradial access for interventional procedures has become increasingly favored over the transfemoral approach. However, radial artery spasm (RAS) and radial artery occlusion (RAO) pose challenges to this approach.AimsThis study aims to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing hydrophilic coated (HC) introducer sheaths with non-coated (NC) introducer sheaths during transradial procedures. The impact on RAS, RAO, periprocedural pain, and complications is evaluated.MethodsPubMed, Embase, and the Cochrane Library were searched for RCTs utilizing HC sheaths in their intervention arm and NC sheaths in the control arm for patients undergoing transradial procedures. Outcomes included incidence of RAS, RAO, pain or discomfort during the procedure, procedure duration, pseudoaneurysm, and hematoma. RevMan 5.4 software was used to analyze pooled risk ratios and mean differences with 95% confidence intervals.ResultsEight RCTs were included in this study. HC sheaths significantly reduced the risk of RAS and periprocedural pain or discomfort compared to NC sheaths (RR = 0.38, 95% CI [0.24, 0.60], I2 = 19% and RR = 0.47, 95% CI [0.37, 0.59], I2 = 1%, respectively). The use of HC sheaths had no significant effect on the risk of RAO, hematoma, or pseudoaneurysm.ConclusionThe use of HC sheaths can enhance the overall patient and operator experience by reducing the risk of RAS and pain during transradial procedures, with no significant effect on RAO, hematoma, or pseudoaneurysm. This study provides evidence supporting the superiority of HC introducer sheaths over NC sheaths during transradial interventions.
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