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Updated: May 16, 2025

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
Juvenile Idiopathic Arthritis and Spondylarthritis
Dov Rosenbaum1,2, Arthur B Meyers3, Patricia Vega-Fernandez4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Abstract:
Juvenile idiopathic arthritis (JIA) is a heterogeneous disorder affecting children < 16 years of age. The clinical heterogeneity translates to imaging, where no specific joint is affected. This article highlights a general imaging approach to JIA, using specific examples of the knee, hand, and wrist as the typical joints affected. We then focus on unique joints that are commonly affected by JIA: the temporomandibular joint, the joints of the upper cervical spine, and the sacroiliac joint. For these latter anatomical sites, regional anatomy and development, location-specific imaging considerations, and arthritis, treatment decision making, and potential differential considerations are reviewed. We highlight, where applicable, a multimodal approach to imaging using developed or developing standardized scoring systems.
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