Spaser Nanoprobes Family for Narrow-Band Multiplexed Cell Imaging.

Area of Science:

• Nanotechnology
• Biophotonics
• Materials Science

Background:

• Spaser nanoprobes offer narrow emission and nanoscale size for biological luminescence.
• Current limitations include challenges in broad spectral wavelength modulation, hindering multiplexed applications.

Purpose of the Study:

• To develop a novel wavelength-tunable spaser system for advanced biological imaging.
• To create a family of nanoprobes with distinct spasing wavelengths for multiplexed sensing.

Main Methods:

• Introduced a novel wavelength-tunable spaser system.
• Investigated energy matching between gain medium and cavity.
• Demonstrated multiplexed imaging using confocal microscopy.

Main Results:

• Created a nanoprobe family with 9 distinct spasing wavelengths (3-8 nm line widths).
• Achieved low pump threshold (0.5 mJ cm⁻²).
• Successfully performed multiplexed imaging of 6 distinct nanoprobes in HeLa cells without spectral crosstalk.

Conclusions:

• Addressed the challenge of wavelength tunability in spaser nanoprobes.
• Clarified luminescence origins in single nanoparticles.
• Paved the way for ultramultiplexed biological imaging and sensing.