RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, clove bud absolute, CAS Registry Number...

Clove bud absolute was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data for components of the NCS do not show a concern for genotoxicity. Clove bud absolute was evaluated for the repeated dose and reproductive toxicity endpoints on the basis of component analysis using a combination of target data, read-across data, and Threshold of Toxicological Concern (TTC); clove bud absolute is safe for use under the conditions described in this safety assessment for the repeated dose and reproductive toxicity endpoints. Data for components of the NCS do not show a concern for skin sensitization under the current declared levels of use. The photoirritation endpoint was evaluated based on ultraviolet/visible (UV/Vis) absorption spectra for the components of the NCS; clove bud absolute is not expected to be photoirritating. The photoallergenicity endpoint was evaluated based on UV/Vis absorption spectra for the components of the NCS; clove bud absolute is not expected to be photoallergenic. The local respiratory toxicity endpoint for this NCS was evaluated using the inhalation TTC for a Cramer Class III material, and the inhalation exposure to clove bud absolute is below the TTC (0.47 mg/day). Based on the component assessment, clove bud absolute does not contain Persistent, Bioaccumulative, and Toxic (PBT) or (very) Persistent, (very) Bioaccumulative (vPvB) components as per the IFRA Environmental Standards and does not present a risk to the aquatic environment at the current reported VoU.