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Viral Mutations

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...

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Updated: May 8, 2025

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies

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Published on: November 29, 2024

[Controversies on Hantavirus].

Teresa Strella¹, Sofía E Echazarreta², Esteban M Couto²

¹Comisión de Infecciones Asociadas al Cuidado de la Salud de Sociedad Argentina de Infectología (SADI) y Hospital Zonal Puerto Madryn, Chubut, Argentina.

|April 8, 2025

Summary

This review addresses controversies in hantavirus transmission and treatment in South America. It clarifies prevention, diagnosis, and management strategies for hantavirus infections, including person-to-person spread.

Keywords:

antiviral hantavirus hantavirus pulmonary syndrome infectious disease transmission plasma zoonoses

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Published on: July 10, 2019

Area of Science:

Infectious Diseases
Epidemiology
Public Health

Context:

Hantavirus infections present unique challenges in South America, including debated transmission routes and limited treatment data.
Emerging infectious disease dynamics necessitate updated differential diagnoses for hantavirus.
Person-to-person transmission of certain hantavirus genotypes in Argentina and Chile complicates infection control.

Purpose:

To review and synthesize current scientific evidence on unresolved controversies surrounding hantavirus infections in Argentina and South America.
To provide expert insights from clinicians managing hantavirus outbreaks with interhuman transmission.
To address critical aspects of hantavirus management, including prevention, diagnosis, and treatment.

Summary:

Discusses adapted respiratory precautions for different hantavirus genotypes and regions.
Examines potential transmission via breastfeeding and identifies laboratory predictors of hantavirus severity.
Evaluates the efficacy of corticosteroids, plasma, and ribavirin in hantavirus treatment and outlines differential diagnoses in Argentina.

Impact:

Aims to raise awareness of scientific evidence for severe hantavirus infections.
Seeks to improve the quality of care and optimize patient outcomes for hantavirus.
Contributes to better prevention and management strategies for hantavirus in the region.