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Rare Histological Types of Breast Cancer: A Single-Center Experience
Mehmet Furkan Sağdıç1, Cihangir Özaslan2
1Department of Surgical Oncology, Ankara Etlik City Hospital, Ankara, Turkey.
The Breast Journal
|April 14, 2025
Summary
This study analyzed 401 rare breast cancer cases, identifying 10 distinct types. Some rare breast carcinomas have good prognoses, while others are associated with poorer outcomes.
Area of Science:
- Oncology
- Pathology
Background:
- Breast carcinoma encompasses over 21 histologies per the 2019 World Health Organization (WHO) classification.
- Rare breast cancer types constitute approximately 5% of all breast cancer diagnoses.
- This research focuses on the clinicopathological characteristics of rare breast cancer subtypes.
Purpose of the Study:
- To investigate the clinicopathological features of rare breast cancer types.
- To analyze the overall survival (OS) and disease-free survival (DFS) associated with these rare subtypes.
- To contribute to the literature on rare breast carcinoma prognoses.
Main Methods:
- Retrospective analysis of 4550 breast carcinoma patients treated between January 2018 and February 2024.
- Identification and classification of 401 cases with rare breast cancer types.
- Evaluation of clinicopathological features, OS, and DFS for each rare subtype.
Main Results:
- Ten rare breast cancer types were identified: mucinous, micropapillary, papillary, metaplastic, neuroendocrine, tubular, cribriform, apocrine, acinic cell, and secretory carcinomas.
- Mucinous, tubular, cribriform, papillary, micropapillary, and secretory carcinomas are associated with a good prognosis.
- Metaplastic, neuroendocrine, apocrine carcinomas, and other rare types show a relatively poor prognosis.
Conclusions:
- Comprehensive analysis of clinicopathological features across rare breast cancer types offers valuable insights.
- Understanding the distinct prognoses of rare breast cancer subtypes is crucial for tailored treatment strategies.
- This study enhances the understanding of rare breast carcinomas, informing future research and clinical practice.
