RIFM fragrance ingredient safety assessment, 1-octanol, CAS registry number 111-87-5

Area of Science:

• Toxicology and Environmental Safety Assessment
• Chemical Safety
• Risk Assessment

Background:

• 1-Octanol is a widely used chemical with potential exposure routes.
• Comprehensive safety evaluations are crucial for regulatory compliance and consumer protection.

Purpose of the Study:

• To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety of 1-octanol.

Main Methods:

• Utilized read-across data from analogs heptyl alcohol and 1-decanol.
• Calculated Margin of Exposure (MOE) for toxicity endpoints.
• Assessed photoirritation/photoallergenicity via UV/Vis spectra.
• Evaluated local respiratory toxicity using the Threshold of Toxicological Concern (TTC).
• Determined environmental safety based on PBT criteria and risk quotients (PEC/PNEC).

Main Results:

• 1-Octanol is not expected to be genotoxic.
• MOE values >100 were calculated for repeated dose, fertility, and developmental toxicity.
• A No Expected Sensitization Induction Level (NESIL) of 10000 μg/cm² was established for skin sensitization.
• 1-Octanol is not predicted to be photoirritating or photoallergenic.
• Exposure is below the TTC for local respiratory toxicity.
• 1-Octanol is not PBT and has environmental risk quotients <1.

Conclusions:

• 1-Octanol presents a low risk for genotoxicity, systemic toxicity, and skin sensitization.
• The substance is not expected to cause photoirritation or local respiratory toxicity.
• Environmental safety assessments indicate no significant environmental risk associated with current use volumes.