Update to RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4.

Area of Science:

• Toxicology
• Environmental Science
• Chemical Safety

Background:

• 1,1-Diethoxyheptane is a chemical compound requiring comprehensive safety evaluation.
• Understanding its toxicological and environmental impact is crucial for risk assessment.

Purpose of the Study:

• To assess the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety of 1,1-diethoxyheptane.
• To determine if exposure levels are within safe limits based on established toxicological and environmental standards.

Main Methods:

• Read-across analog data from octanal dimethyl acetal for genotoxicity assessment.
• Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) for toxicity endpoints.
• UV/Vis spectra for photoirritation/photoallergenicity.
• International Fragrance Association (IFRA) Environmental Standards for PBT assessment.
• PEC/PNEC ratio calculation for environmental risk assessment.

Main Results:

• 1,1-Diethoxyheptane is not expected to be genotoxic.
• Exposure levels are below the TTC for repeated dose, reproductive, and local respiratory toxicity.
• Exposure is below the DST for skin sensitization.
• No photoirritation or photoallergenicity is expected.
• The substance is not Persistent, Bioaccumulative, and Toxic (PBT) and has environmental risk quotients <1.

Conclusions:

• 1,1-Diethoxyheptane presents a low risk for genotoxicity, systemic toxicity, and local effects.
• The substance is not expected to be a skin sensitizer or a photoirritant/photoallergen.
• Environmental safety is confirmed, with no PBT concerns and acceptable risk quotients.