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Serum and Tissue Periostin Expression in Rhinosinusitis With Nasal Polyps
Gerasimos Danielides1, Spyridon Lygeros1, Georgios Kyriakopoulos2
1Department of Otorhinolaryngology, Medical School, University of Patras, Patras, Greece.
American Journal of Rhinology & Allergy
|April 29, 2025
Summary
Periostin protein is elevated in nasal polyps, suggesting a key role in chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis. This finding highlights periostin as a potential therapeutic target for CRSwNP.
Area of Science:
- Immunology
- Otolaryngology
- Biochemistry
Background:
- Chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis involves periostin.
- Investigating periostin's role in CRSwNP is crucial.
Purpose of the Study:
- To examine periostin expression in nasal polyp tissue and serum.
- To evaluate periostin as a potential biomarker for CRSwNP.
Main Methods:
- Assessed POSTN gene mRNA, protein levels via ELISA/Western Blot in 36 CRSwNP patients and 12 controls.
- Measured serum periostin levels in CRSwNP patients and controls.
Main Results:
- Significantly elevated periostin mRNA and protein in CRSwNP tissues versus controls (P<.05).
- Positive correlation between periostin levels and asthma/smoking in CRSwNP patients.
- No significant difference in serum periostin between CRSwNP patients and controls.
Conclusions:
- Periostin upregulation in nasal polyps suggests a critical role in CRSwNP development and progression.
- Periostin emerges as a promising therapeutic target for CRSwNP.
