Unconventional approaches for synthesis of 2-substituted benzothiazoles
Fatemeh Doraghi1, Mohammad Hadi Edareh2, Mehdi Ghanbarlou1
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@sina.tums.ac.ir.
Abstract:
Benzothiazoles are among the most important heterocycles in pharmaceuticals, natural products, and functional materials. Hence, developing direct and sustainable routes by replacing hazardous/toxic thiol reagents with nontoxic reagents for constructing 2-substituted benzothiazoles is of utmost importance. In this review, we have highlighted many synthetic methods for the synthesis of 2-substituted benzothiazoles from different starting materials under transition metal catalysis or metal-free systems.
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