RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho wood oil, CAS Registry Number...

Ho wood oil was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data for the components of the NCS do not show a concern for genotoxicity. Ho wood oil was evaluated for the repeated dose and reproductive toxicity endpoints on the basis of component analysis using a combination of target data, read-across data, and Threshold of Toxicological Concern (TTC); ho wood oil is safe for use under the conditions described in this safety assessment for the repeated dose and reproductive toxicity endpoints. Data for components of the NCS do not show a concern for skin sensitization under the current, declared levels of use. The photoirritation endpoint was evaluated based on the UV/Vis absorption spectra for the components of the NCS; ho wood oil is not expected to be photoirritating. The photoallergenicity endpoint was evaluated based on the UV/Vis absorption spectra for the components of the NCS; ho wood oil is not expected to be photoallergenic. The local respiratory toxicity endpoint for this NCS was evaluated using the inhalation TTC for a Cramer Class III material, and the inhalation exposure to ho wood oil is below the TTC (0.47 mg/day). Based on the component assessment, ho wood oil does not contain Persistent, Bioaccumulative, and Toxic (PBT) or (very) Persistent, (very) Bioaccumulative (vPvB) components as per the IFRA Environmental Standards and does not present a risk to the aquatic environment at the current reported VoUs.