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Rhesus D Immune Globulin in Early Pregnancy: A Clinical Review

Stevie L Muscarella1, Brianne Morgan1, Sarah Horvath1

  • 1Department of Obstetrics and Gynecology, Penn State College of Medicine, 500 University Drive, Mail Code H103, Hershey, PA 17033, USA.

Obstetrics and Gynecology Clinics of North America
|May 4, 2025
PubMed

Keywords:
First-trimester bleedingGuidelinesProphylaxisRhD immune globulin (RhIg)Sensitization

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
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