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Structures and mechanisms of AAA+ protein complexes in DNA processing.

Alexander Carver1, Bowen Zhang1, Xiaodong Zhang1

  • 1Section of Structural and Synthetic Biology, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK; Laboratory of DNA Processing Machines, The Francis Crick Institute, London, NW1 1AT, UK.

Current Opinion in Structural Biology
|May 7, 2025
PubMed
Summary

AAA+ proteins are essential ATPases that process DNA. Recent cryoEM structures reveal how these AAA+ proteins disassemble complexes by translocating peptides, often acting as hexamers.

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