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Updated: May 13, 2025
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Reflexive Drug Testing Strategies for Efficient Utilization of Resources and Better Interpretation
Ari Pape1, Andrew N Hoofnagle1, Hsuan-Chieh Liao1
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific Street, Room NW120, University Of Washington Medical Center NW120, Seattle, WA 98195-7110, USA.
Strategic urine drug testing improves patient compliance and reduces opioid abuse. Implementing risk assessment, pathologist oversight, and informatics optimizes laboratory workflows for better patient care.
Area of Science:
- Clinical Chemistry
- Toxicology
- Laboratory Medicine
Background:
- Urine drug testing (UDT) is essential for managing the opioid crisis.
- UDT provides critical data on patient adherence and potential substance misuse.
Purpose of the Study:
- To review and emphasize strategic approaches for optimizing UDT.
- To enhance the accuracy of UDT interpretation and clinical utility.
Main Methods:
- Adoption of strategic test ordering.
- Implementation of risk assessment and pathologist oversight.
- Application of reflex algorithms and informatics tools for workflow optimization.
Main Results:
- Streamlined laboratory workflows and improved interpretation accuracy.
- Effective navigation of limitations across different testing methodologies.
- Enhanced data analysis and integration of clinical information.
Conclusions:
- Strategic approaches significantly improve the effectiveness of UDT.
- Optimized UDT directly contributes to enhanced patient care in opioid management.
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