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Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

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Related Experiment Video

Updated: May 13, 2025

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Microbial Influences on Irritable Bowel Syndrome.

Eamonn M M Quigley¹

¹Lynda K and David M Underwood Center for Digestive Health, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA.

Gastroenterology Clinics of North America

|May 10, 2025

Summary

Researchers investigated the gut microbiome

Area of Science:

Microbiology and Gastroenterology

Background:

The role of gut microbes in irritable bowel syndrome (IBS) pathogenesis is increasingly recognized.
Previous studies on the IBS microbiome often relied on fecal samples, limiting comprehensive analysis.
Advanced 'omics' technologies offer a deeper understanding of the gut microbiome and its metabolic functions.

Purpose of the Study:

To explore the potential for a distinct microbial signature in irritable bowel syndrome (IBS).
To assess the utility of metagenomics and metabolomics in characterizing the IBS microbiome.

Main Methods:

Application of molecular microbiological tools, including metagenomics and metabolomics.
Analysis of gut microbial composition and metabolic activity.

Main Results:

Keywords:

Irritable bowel syndrome Metabolome Microbiome Postinfection irritable bowel syndrome Small intestinal bacterial overgrowth

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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

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No specific microbial signature characteristic of irritable bowel syndrome (IBS) has been identified to date.
The heterogeneity of IBS phenotypes and individual microbiome profiles contributes to this lack of a distinct signature.

Conclusions:

Current 'omics' data do not support a universal microbial signature for irritable bowel syndrome (IBS).
The complex interplay between host factors and diverse microbial communities challenges the identification of a singular IBS microbiome.