Related Experiment Video
Updated: May 15, 2025

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
[Treatment of rheumatoid arthritis with janus kinase inhibitors]
Pernille Holme Thorhauge1, Lars Løkke Ottesen1,2, Niels Lomborg1,2
1Medicinsk Afdeling, Sygehus Lillebælt - Vejle.
Abstract:
Rheumatoid arthritis (RA) is a frequent systemic inflammatory polyarthritis. In recent years, considerable knowledge has been gained in the treatment and diagnosis field. This review will address RA in general, focusing on the effect of the newest treatment option: janus kinase (JAK) inhibitors. Furthermore, using JAK inhibitors to treat RA in a Danish context will be discussed. In conclusion, JAK inhibitor treatment is an effective treatment for rheumatoid arthritis - however, potential serious side effects and a high price limit its use.
Related Concept Videos
The JAK-STAT Signaling Pathway
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...

