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Polymer-Conjugated SOD-Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia-Reperfusion Injury During
Shengzhou Li1, Fei Duan2, Zhiwen Qiu2
1Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
Advanced Healthcare Materials
|May 21, 2025
Summary
This study developed a novel antioxidant system to combat kidney transplant injury caused by reactive oxygen species (ROS). The system enhances enzyme stability and delivery, significantly reducing organ damage and inflammation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nephrology
Background:
- Ischemia-reperfusion injury (IRI) in kidney transplantation causes oxidative stress from reactive oxygen species (ROS), worsening organ shortages.
- Protein-based antioxidants and nanozymes show promise but suffer from poor stability and low therapeutic efficacy.
- Improving antioxidant stability and delivery is crucial for mitigating IRI and enhancing transplant outcomes.
Purpose of the Study:
- To develop a stable and efficient antioxidant system for scavenging ROS and reducing IRI in kidney transplantation.
- To enhance the stability and intracellular delivery of superoxide dismutase (SOD) using functional polymers and nanozymes.
- To create a novel cascade biocatalyst for improved ROS scavenging and reduced kidney damage.
Main Methods:
- Conjugation of superoxide dismutase (SOD) with functional polymers to form micelles for enhanced stability and delivery.
- In situ growth of platinum nanozymes (Pt0) on SOD micelles to create a cascade biocatalyst (SOEP).
- Evaluation of the SOEP system's enzymatic activity, ROS scavenging capacity, and therapeutic effects on IRI in a kidney transplantation model.
Main Results:
- Functional polymer conjugation significantly improved SOD stability and endo/lysosomal escape, preserving enzymatic activity.
- The in situ growth of Pt0 nanozymes on SOD micelles minimally impacted SOD activity, creating an efficient cascade biocatalyst.
- The SOEP system demonstrated effective cascade ROS scavenging, significantly reducing kidney damage and inflammation associated with IRI.
Conclusions:
- The developed polymer-conjugated SOD micelles with in situ grown Pt0 nanozymes offer a promising strategy for mitigating IRI in kidney transplantation.
- This novel approach enhances antioxidant stability and delivery, providing a potential solution to reduce organ shortages.
- The study presents a new avenue for developing advanced therapeutic strategies for organ transplantation complications.
