[Immune response and the formation of immunologic memory to Staphylococcus in mice of different genotypes]

The time course of changes in the number of antibody-forming cells in the spleen in the primary and secondary immune response to staphylococcal corpuscular antigen was studied in experiments on mice. C3H mice were found to be highly responsive, while A/Sn mice showed low response, the opposite character of immune responsiveness to this antigen in the animals of the above-mentioned genotypes increasing after the second immunization. C57BL/6, CBA, DBA/2, BALB/c and (CBA X C57BL/6) F1 mice showed comparatively moderate antibody formation in response to staphylococci. The formation of immunological memory to this antigen depended on the genotype of mice and was determined by the intensity of antigenic action: high priming doses of staphylococci proved to be most effective; low doses of the antigen were not effective or produced only short-term immunological memory to staphylococci in mice.