Silver Nanoparticles for Biosensing and Drug Delivery: A Mechanical Study on DNA Interaction

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Silver nanoparticles (AgNPs) possess unique physicochemical properties like surface plasmon resonance and tunable size.
• AgNPs are increasingly utilized as nanocarriers for targeted drug delivery and in biosensing platforms.
• Functionalization of AgNPs enables their application in advanced biomedical diagnostics and therapeutics.

Purpose of the Study:

• To explore synthesis strategies and functionalization of AgNPs for drug delivery and biosensing.
• To investigate the potential of AgNPs in enhancing anticancer drug efficacy and biosensor sensitivity.
• To analyze the mechanistic aspects of AgNP-mediated reactive oxygen species generation and drug release.

Main Methods:

• Review of AgNP synthesis methods, including chemical and green approaches.
• Functionalization of AgNPs with doxorubicin (DOX) for anticancer drug delivery.
• Development and evaluation of electrochemical and optical biosensors utilizing AgNPs.

Main Results:

• AgNPs demonstrate improved therapeutic efficacy by exploiting tumor microenvironment conditions (e.g., low pH).
• AgNPs enhance biosensor sensitivity through surface plasmon resonance and electrochemical signal amplification.
• Experimental data provide insights into reactive oxygen species generation, drug release kinetics, and sensor performance.

Conclusions:

• AgNP-based nanocarriers represent a potent platform for precision oncology and medical diagnostics.
• AgNPs effectively improve drug delivery and enable sensitive biomarker detection.
• The study highlights the dual role of AgNPs in enhancing therapeutic outcomes and diagnostic capabilities.