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Single-use technology (SUT) is widely adopted across biopharmaceutical manufacturing for its benefits. This review covers SUT products, applications, and Switzerland

Keywords:
BiotherapeuticsProcess intensification and continuous manufacturingSingle-use facilitiesSingle-use systems and process platforms

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Area of Science:

  • Biotechnology and Pharmaceutical Manufacturing
  • Process Engineering
  • Materials Science

Background:

  • Single-use technology (SUT) is increasingly prevalent in both classic biologics and advanced therapy medicinal products (ATMPs) manufacturing.
  • The advantages of SUT, including flexibility and reduced contamination risk, drive its widespread adoption in laboratory and production settings.

Purpose of the Study:

  • To provide an updated overview of available single-use products, manufacturers, and suppliers.
  • To discuss process examples, facility design, and configuration for SUT implementation.
  • To highlight Switzerland's leading role in SUT development and adoption.

Main Methods:

  • Review of milestones in single-use systems and platform technologies.
  • Analysis of current market offerings and supplier landscape.
  • Case study examples of SUT implementation in biopharmaceutical processes.

Main Results:

  • SUT is extensively used across various scales, from lab applications to large-scale production.
  • The market offers a wide range of SUT products from numerous suppliers.
  • SUT adoption extends beyond the biopharmaceutical sector, indicating broader applicability.

Conclusions:

  • Single-use technology is a well-established and expanding area in bioprocessing and beyond.
  • The continuous development and implementation of SUT, particularly with Swiss innovation, are shaping modern manufacturing.
  • SUT offers significant advantages, leading to its ubiquitous presence and ongoing integration into diverse industrial applications.