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Interferon-γ Therapy in Patients With Refractory Disseminated Coccidioidomycosis
Chen Wang1, Brenna A LaBere2, Michell M Lozano Chinga2
1Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Summary
Refractory disseminated coccidioidomycosis (DCM) is a severe fungal infection. Adjunctive interferon-gamma therapy shows promise for treating refractory DCM, especially in patients lacking specific genetic mutations.
Area of Science:
- Mycology
- Immunology
- Infectious Diseases
Background:
- Refractory disseminated coccidioidomycosis (DCM) presents significant therapeutic challenges.
- Limited effective treatment options exist for severe, persistent coccidioidomycosis infections.
Purpose of the Study:
- To review the efficacy of adjunctive interferon-gamma (IFN-γ) therapy.
- To evaluate treatment outcomes in patients with refractory DCM.
Main Methods:
- Retrospective review of institutional and published case experiences.
- Analysis of patient responses to adjunctive IFN-γ therapy.
Main Results:
- Overall favorable responses were observed with adjunctive IFN-γ therapy.
- Patients without signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations showed positive outcomes.
Conclusions:
- Adjunctive interferon-γ therapy is a potentially effective treatment modality for refractory DCM.
- STAT1 gain-of-function mutations may predict a lack of response to IFN-γ therapy in DCM.
Keywords:
antifungal therapiesdisseminated coccidioidomycosisinterferon-γinvasive fungal diseasesignal transducer and activator of transcription 1More Related Videos
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