Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of Impella 5.5 on right ventricular load and adaptation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Same author

Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis.

Circulation. Heart failure·2026

Same author

Aortic Pulsatility Index Predicts Native Recovery in Patients With Cardiogenic Shock Supported by Intra-aortic Balloon Pumps.

Journal of cardiac failure·2025

Same author

Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study.

Journal of cardiac failure·2025

Same author

Pericardial Mass as a Rare Cause of Unstable Angina in a Young Veteran.

JACC. Case reports·2025

Same author

Incidence and Characteristics of ST-Elevation Myocardial Infarction in Patients With Previous Coronary Artery Bypass Grafting: A Single-Center Experience.

Cureus·2025

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

When Do Microbubbles Become Macrobubbles in Laser PCI?

Ilgizar Hart¹, Molly Silkowski¹, Payton Kendsersky¹

¹Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, USA.

JACC. Case Reports

|May 30, 2025

Summary

This summary is machine-generated.

Laser atherectomy using contrast can cause macrobubble formation, leading to embolization and hemodynamic issues. Diluting contrast may reduce this risk during coronary interventions.

Keywords:

ELCA high-risk PCI laser atherectomy microbubbles formation

More Related Videos

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

Related Experiment Videos

Last Updated: Sep 19, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

Area of Science:

Cardiology
Interventional Cardiology
Medical Devices

Background:

Laser atherectomy is used for treating complex coronary artery disease.
Contrast media is essential for visualizing vessels during laser atherectomy.
Microbubble formation is a known complication, potentially causing distal embolization.

Observation:

A case study involving a 64-year-old female with severe calcified in-stent restenosis and stent underexpansion.
Treatment involved excimer laser coronary atherectomy.
The procedure was complicated by macrobubble formation, resulting in slow reflow, hypotension, and bradycardia.

Findings:

Excimer laser coronary atherectomy with angiographic contrast can lead to macrobubble formation.
Macrobubbles can cause distal embolization, slow reflow, and hemodynamic compromise.
This complication occurred despite the procedure targeting in-stent restenosis.

Implications:

Diluting contrast media may be a strategy to mitigate macrobubble formation during laser atherectomy.
Awareness of this complication is crucial for interventional cardiologists.
Further research may be needed to optimize contrast use in laser atherectomy procedures.