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Updated: Jun 14, 2025

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Metal-Free Electrophilic Phosphination with Soft Carbon Nucleophiles: Access to Diverse β-Ketophosphine Oxides
Da-Wei Shi1, Ming Li1, Zhi-Chao Wang1
1College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, P. R. China.
Abstract:
A metal-free electrophilic phosphination protocol utilizing silyl enol ethers as soft carbon nucleophiles has been developed under Tf2O/DMSO-mediated conditions. This approach enables convenient access to a diverse range of β-ketophosphine oxides under mild reaction conditions. The broad substrate scope, scalability, and potential for further synthetic applications highlight the practical utility of this method. The development of this method also expands the scope of the umpolung electrophilic phosphination strategies.
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