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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Sep 19, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

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Primary Cutaneous SMARCA4-Deficient Tumor With Metastases.

Supriya Pradhan¹, Martha Lehman², Abdul Mohd Tahir³

¹Departments of Anatomical Pathology, New South Wales Health Pathology, Coffs Harbour, Australia.

Journal of Cutaneous Pathology

|June 4, 2025

Summary

This summary is machine-generated.

SMARCA-4 deficient cutaneous tumors are rare and aggressive. Early recognition of their high-grade morphology and lack of SMARCA-4 protein is crucial for diagnosis and treatment.

Area of Science:

Oncology
Dermatopathology

Background:

SMARCA-4 deficient cutaneous tumors are exceptionally rare.
These aggressive neoplasms present with high-grade morphology.

Keywords:

SMARCA4 SMARCA4‐deficient undifferentiated malignant neoplasm metastases skin tumor undifferentiated skin tumor

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