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Updated: Jun 19, 2026

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Biomedical Treatment Nanomotors Based on the Intestinal Axis: Current Challenges.

Lin Zhang¹, Yongsheng Du¹, Weixin Wang¹

¹Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai 264003, P. R. China.

ACS Applied Bio Materials

|June 11, 2025

Summary

This summary is machine-generated.

Nanomotors offer a promising new approach to treating inflammatory bowel disease (IBD) by overcoming the limitations of traditional therapies targeting the gut

Keywords:

gut microbes inflammatory bowel disease intestinal axis nanomotor passive transportation

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Area of Science:

Gastroenterology and Nanomedicine

Background:

The gut microbiome plays a critical role in the intestinal axis, influencing physiological and pathological processes.
Imbalances in gut microbial homeostasis are characteristic of inflammatory bowel disease (IBD).
Gut microbes and their metabolites communicate with organs along the intestinal axis, impacting disease progression.

Purpose of the Study:

To review the application of nanomotors in treating IBD.
To explore the challenges and future directions of nanomotor-based therapies for IBD targeting the intestinal axis.

Main Methods:

Literature review focusing on nanomotor applications in IBD treatment.
Analysis of nanomotor capabilities in active targeting and energy conversion.
Examination of nanomotor advantages over traditional drug delivery for intestinal axis-based therapies.

Main Results:

Nanomotors demonstrate active targeting and self-propulsion, overcoming passive drug delivery limitations.
Their selectivity and initiative offer potential solutions for IBD therapies targeting the intestinal axis.
Current nanomotor applications in IBD treatment face specific difficulties that require further investigation.

Conclusions:

Nanomotors represent a novel therapeutic strategy for IBD by enabling targeted interventions along the intestinal axis.
Further research is needed to address current difficulties and fully realize the potential of nanomotor-based IBD treatments.
Nanomotor technology holds promise for advancing IBD management through innovative approaches to the intestinal axis.