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Related Concept Videos

Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

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Updated: Jun 4, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
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Nanomachines Based on Inner Ultrasonic Multiple Scattering for Ameliorating Renal Function.

Rui Gao1, Yongsheng Du1, Yu Dong1

  • 1Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new nanomachine for acute kidney injury (AKI) treatment. This device uses ultrasound and current to navigate, protect kidney cells, and reduce injury through targeted therapies.

Keywords:
AKI, BaTiO3NO/O2TMAO targeted metabolomicsnanomachine

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Use of 3D Robotic Ultrasound for In Vivo Analysis of Mouse Kidneys
08:21

Use of 3D Robotic Ultrasound for In Vivo Analysis of Mouse Kidneys

Published on: August 12, 2021

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Renal Medicine

Background:

  • Acute kidney injury (AKI) presents a significant challenge in cell and tissue protection.
  • Current therapeutic strategies for AKI often face limitations in efficacy and targeted delivery.
  • Developing advanced methods for active kidney-trauma inhibition is crucial for improved patient outcomes.

Purpose of the Study:

  • To introduce a novel current-ultrasound conversion-propelled wireless nanomachine for AKI treatment.
  • To demonstrate the potential of this nanomachine in actively inhibiting kidney-trauma formation.
  • To establish a new technological approach for highly efficient kidney protection.

Main Methods:

  • Fabrication of Au@PASP-PArg/BaTiO3 (ASPB) nanomachine with gold-covered PASP-PArg/BaTiO3.
  • Utilizing ASPB's dielectric and piezoelectric properties for guided navigation under current.
  • Triggering endogenous ultrasound to induce surface charge imbalance, generating reactive oxygen species (ROS) and oxygen.

Main Results:

  • ASPB generated hydrogen peroxide (H2O2) and singlet oxygen (1O2) via oxidation-reduction reactions.
  • ASPB decomposed water to produce oxygen (O2) and catalyzed polyarginine to release nitric oxide (NO).
  • Navigated ASPB released NO/O2 and utilized endogenous current to protect renal tissues by modulating MYDGF, KCNQ1, and TMAO.

Conclusions:

  • The developed current-ultrasound conversion-propelled nanomachine offers a promising new technology for AKI treatment.
  • Accurate navigation and endogenous ultrasound triggering enable targeted generation of therapeutic agents.
  • This approach demonstrates significant potential for highly efficient kidney-function protection and injury mitigation.