Nanomachines Based on Inner Ultrasonic Multiple Scattering for Ameliorating Renal Function

Protecting cell/tissue disservice during acute kidney injury (AKI) was an important but still challenging goal. Here, we proposed a current-ultrasound convertion-propelled wireless positioning and tracking nanomachine in which Au covered one side of a PASP-PArg/BaTiO₃ footplate (Au@PASP-PArg/BaTiO₃, ASPB). These navigational nanomaches were used in the treatment of AKI to confirm a new technology and method for actively inhibiting kidney-trauma formation to enable highly efficient kidney-protection. ASPB possessed the high dielectric constant and piezoelectric properties, which acquired endogenous ultrasound-current and guided navigation under exogenous current excitement. Under the triggering of endogenous ultrasound, ASPB further gave rise to the unbalanced charges on its surface and underwent oxidation-reduction reactions with surrounding water, obtaining H₂O₂ and ¹O₂; meanwhile, ASPB could also decompose water to produce O₂ under the inducement of endogenous ultrasound. Additionally, the attained H₂O₂ and ¹O₂ catalyzed polyarginine to discharge NO. Importantly, under accurate navigation, endogenous ultrasound-triggered gas sensor discharged NO/O_2, and endogenous current could protect renal tissues from damage based on modulating MYDGF expressions, KCNQ1 functions, and TMAO targeted metabolomics. These current-ultrasound convertion-pushed navigational nanomaches clearly unveiled illustrious potential for promoting highly efficient kidney-function protection.