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Association of MMP-11 Genotypes With Colorectal Cancer in Taiwan.
Tao-Wei Ke1,2, Ming-Hsien Wu3,4,5, Ying-Jing Chen6
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.
In Vivo (Athens, Greece)
|June 27, 2025
Summary
Investigating matrix metalloproteinase-11 (MMP-11) single-nucleotide polymorphisms (SNPs) in Taiwanese colorectal cancer (CRC) patients revealed no link to cancer susceptibility. However, specific MMP-11 genotypes showed potential as prognostic biomarkers for tumor size and clinical stage.
Area of Science:
- Genetics
- Oncology
- Biochemistry
Background:
- Matrix metalloproteinase-11 (MMP-11) plays a role in extracellular matrix remodeling.
- Genetic variations in MMP-11 may influence cancer development and progression.
Purpose of the Study:
- To examine the association between four MMP-11 single-nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) susceptibility in a Taiwanese population.
- To explore the potential of these MMP-11 SNPs as biomarkers for CRC prognosis.
Main Methods:
- Genotyping of 362 CRC patients and controls for MMP-11 SNPs (rs738791, rs2267029, rs738792, rs28382575) using restriction fragment length polymorphism.
- Statistical analysis to compare genotype and allele frequencies between cases and controls.
- Assessment of Hardy-Weinberg equilibrium for all loci.
Main Results:
- No significant association was found between the studied MMP-11 SNPs and CRC susceptibility.
- Allelic analyses did not reveal any link between the SNPs and overall CRC risk.
- The rs738791 genotypes (CT/TT) were associated with larger tumor size and absence of metastasis.
- The rs2267029 genotypes (AG/AA) were significantly linked to advanced clinical stages (III-IV).
Conclusions:
- The investigated MMP-11 polymorphisms are not associated with colorectal cancer susceptibility.
- Specific MMP-11 genotypes (rs738791 and rs2267029) may serve as potential prognostic biomarkers for CRC.
