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Published on: June 7, 2019
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Mohs Micrographic Surgery for Melanoma
Joshua Burshtein1, Justin Marson2, Milaan Shah3
1Department of Dermatology, University of Illinois-Chicago, Chicago, IL, USA.
Dermatologic Clinics
|June 28, 2025
Summary
Mohs micrographic surgery (MMS) offers a tissue-sparing approach for skin cancer treatment. Evidence suggests MMS may lower melanoma recurrence rates, particularly with immunostaining, though challenges exist.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Mohs micrographic surgery (MMS) is a specialized tissue-sparing technique for cutaneous malignancies.
- Guidelines recommend wide local excision for noninvasive melanoma.
- MMS is considered for specific melanoma subtypes like in-situ and lentigo maligna.
Purpose of the Study:
- To explore the evidence supporting Mohs micrographic surgery for melanoma treatment.
- To discuss the challenges associated with using MMS for melanoma.
Main Methods:
- Review of existing literature on Mohs micrographic surgery for melanoma.
- Analysis of recurrence rates and the role of immunostaining.
Main Results:
- Mohs micrographic surgery (MMS) shows potential for lower melanoma recurrence rates.
- Immunostaining may enhance the effectiveness of MMS in melanoma treatment.
Conclusions:
- MMS is a viable option for select melanoma cases, including melanoma-in-situ and lentigo maligna.
- Further exploration of MMS benefits and challenges in melanoma management is warranted.
