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Updated: Sep 17, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Reductive Arylation of Secondary Amides with Aryl Boronic Acids via C═O Bond Cleavage by Ruthenium Catalysis
Yilin Ma1, Wei Zhou1, Chengwei Liu1
1Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
Abstract:
A general and practical ruthenium-catalyzed reductive arylation of secondary amides with readily available arylboronic acids via C═O bond cleavage is reported. The synthesis of amides to secondary alkyl amines could be realized in only one step under the ligand-free and additive-free conditions. Furthermore, the desired products obtained from this reaction could be applied to multistep and diversified synthesis of complicated molecules and bioactive molecules. A broad substrate scope and excellent functional group tolerance have been demonstrated for this method.
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