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Delayed Diagnoses of Cardiac Amyloidosis
Cooper B Kersey1, Graham Bevan1, Douglas Leedy1
1Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA.
JACC. Case Reports
|July 11, 2025
Summary
Diagnosing cardiac sarcoidosis is difficult. Multimodality imaging can misdiagnose it, with three cases reclassified to wild-type transthyretin cardiac amyloidosis after biopsy.
Area of Science:
- Cardiology
- Medical Imaging
- Histopathology
Background:
- Cardiac sarcoidosis (CS) diagnosis is challenging due to low endomyocardial biopsy sensitivity.
- Cardiac 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has limited specificity for CS.
Observation:
- Three patients were initially diagnosed with isolated CS.
- Diagnosis was based on multimodality cardiac imaging findings.
Findings:
- Endomyocardial biopsy histopathology definitively reclassified these patients.
- The confirmed diagnosis for all three was wild-type transthyretin cardiac amyloidosis.
Implications:
- This highlights potential diagnostic pitfalls in CS evaluation.
- Multimodality imaging findings must be carefully correlated with histopathology.
- Distinguishing CS from cardiac amyloidosis is critical for appropriate treatment.
Keywords:
cardiac amyloidosiscardiac sarcoidosiscase reportmultimodality imagingnonischemic cardiomyopathyMore Related Videos
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