Association between metabolic syndrome and cataract: a meta-analysis.

Area of Science:

• Ophthalmology
• Metabolic Diseases
• Public Health

Background:

• Metabolic syndrome (MetS) is a growing concern linked to various health issues.
• Previous studies suggest a potential association between MetS and an increased risk of cataract, but evidence is inconclusive.

Purpose of the Study:

• To systematically evaluate and clarify the association between metabolic syndrome and the risk of developing cataracts in adults.

Main Methods:

• A meta-analysis of observational studies was conducted, searching PubMed, Embase, and Web of Science.
• Data from 10 studies involving 379,464 participants were pooled using a random-effects model.
• Risk ratios (RR) with 95% confidence intervals (CI) were calculated, and heterogeneity was assessed.

Main Results:

• Metabolic syndrome was significantly associated with an increased risk of cataract (RR: 1.28, 95% CI: 1.16-1.41).
• The association was more pronounced in individuals aged 57 years and older.
• Stronger associations were observed when using the International Diabetes Federation criteria for MetS diagnosis.

Conclusions:

• Metabolic syndrome is a significant risk factor for cataract development in adults.
• Older populations appear to be more susceptible to this association.
• Further research is recommended to elucidate underlying mechanisms and inform prevention strategies.